GHK-Cu (glycyl-L-histidyl-L-lysine–copper complex) is a naturally occurring copper-binding peptide found in human plasma, saliva, and tissue. It plays an essential role in skin repair, hair growth, and cellular regeneration. In this formulation, GHK-Cu is paired with Zn-Thymulin, a zinc-bound thymic peptide that enhances immune modulation and promotes hair follicle vitality.
Mechanistically, GHK-Cu activates a wide array of gene-repair and remodeling pathways, stimulating collagen and glycosaminoglycan synthesis, improving angiogenesis, and modulating inflammatory cytokines. Zn-Thymulin complements this activity by regulating keratinocyte proliferation and protecting against oxidative stress, resulting in improved skin tone, elasticity, and hair follicle function.
GHK-Cu (Zn-Thymulin / GHK-Cu) – 30 mL has shown the following potential in studies:
Additional research is needed to confirm potential benefits and research indications.
Regenerative and Protective Actions of the GHK-Cu Peptide (Pickart & Margolina, 2018)
This review highlights the broad biological activities of GHK-Cu, including stimulation of collagen, elastin, and glycosaminoglycan synthesis, blood vessel and nerve outgrowth, and cellular protection. It demonstrates GHK-Cu’s potential in tissue repair across multiple organs and its anti-inflammatory, antioxidant, and DNA-repair actions, suggesting it acts as a master regulator of gene expression promoting regeneration.
GHK Peptide as a Natural Modulator of Skin Regeneration (Pickart, Vasquez-Soltero, & Margolina, 2015)
This article discusses how GHK-Cu supports skin repair by stimulating collagen and glycosaminoglycan synthesis and modulating metalloproteinases. The peptide rejuvenates fibroblast activity, enhances wound healing across tissues, and improves skin elasticity and tone. It has been proposed as a therapeutic candidate for skin inflammation, COPD, and cancer through regulation of over 4,000 human genes related to repair and regeneration.
Beneficial Effects of GHK-Cu in Experimental Colitis (Mao et al., 2025)
In a DSS-induced murine model of ulcerative colitis, GHK-Cu significantly reduced inflammation, weight loss, and mucosal injury. Mechanistically, it enhanced epithelial barrier integrity by upregulating tight-junction proteins (ZO-1, Occludin) and modulating the SIRT1/STAT3 pathway. These results indicate that GHK-Cu may promote mucosal healing and suppress inflammatory signaling, positioning it as a promising therapeutic candidate for inflammatory bowel disease.
Zn-Thymulin Hair Growth Study (Vickers, 2017)
A clinical analysis evaluated topical zinc-thymulin (ZT) in 18 adults (17 men, 1 woman) with androgenetic alopecia over 4–10 months. The study found significant increases in vellus and intermediate hair density and visible melanogenesis after 6 months, with no adverse effects or drug interactions reported. The results suggest that ZT safely stimulates and maintains the anagen phase, supporting its use as a novel treatment for hair loss.
Note: Individual results may vary. This peptide combination is not FDA-approved for the treatment, cure, or prevention of any disease, and its use may be considered investigational and not for human or animal consumption. The information is based on published research and is educational in nature. This information should not be interpreted as medical advice. Individuals should consult with a licensed healthcare provider to discuss any plans of care.
*While individual peptides have been studied for various potential benefits, there is little to no clinical research on their combined use. Multi-peptide protocols remain experimental, and safety, efficacy, and interaction data are not well established.
Mao, S., Huang, J., Li, J., Sun, F., Zhang, Q., Cheng, Q., Zeng, W., Lei, D., Wang, S., & Yao, J. (2025) ‘Exploring the Beneficial Effects of GHK-Cu on an Experimental Model of Colitis and the Underlying Mechanisms’, Frontiers in Pharmacology, 16, 1551843. Available at: https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1551843/full (Accessed: 11 November 2025).
Pickart, L., Vasquez-Soltero, J. M., & Margolina, A. (2015) ‘GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration’, BioMed Research International, 2015, 648108. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC4508379/ (Accessed: 11 November 2025).
Pickart, L., & Margolina, A. (2018) ‘Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data’, International Journal of Molecular Sciences, 19(7), 1987. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC6073405/ (Accessed: 11 November 2025).
Vickers, E. R. (2017) ‘An analysis of the safety and efficacy of topical Zinc-Thymulin to treat androgenetic alopecia’, Hair Therapy & Transplantation, 7. Available at: https://www.researchgate.net/publication/322674332_An_Analysis_of_the_Safety_and_Efficacy_of_Topical_Zinc-Thymulin_to_treat_Androgenetic_Alopecia (Accessed: 11 November 2025).
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