Epithalon (also known as Epitalon or Epithalamin) is a synthetic tetrapeptide composed of four amino acids: alanine, glutamic acid, aspartic acid, and glycine. It was originally derived from a naturally occurring pineal gland peptide complex associated with aging and circadian regulation.
Epithalon is thought to work by activating the enzyme telomerase, which helps maintain or restore the length of telomeres—the protective ends of chromosomes that shorten with age. By supporting telomere stability and promoting cellular renewal, Epithalon may contribute to improved cellular longevity and regulation of oxidative stress. It has also been studied for its potential influence on melatonin production and circadian rhythm balance.
Epithalon has shown the following potential in studies:
Additional research is needed to confirm potential benefits and research indications.
Epithalon and Telomerase Activation (Khavinson et al., 2003)
In cultured human cells, Epithalon exposure was associated with activation of telomerase, the enzyme involved in maintaining telomere length. This correlation suggests that Epithalon may influence cellular aging pathways, although further research is needed to clarify its effects in living organisms.
Epithalon’s Anti-Aging Effects in Mice (Anisimov et al., 2003)
In a long-term mouse study, lifetime administration of Epithalon correlated with extended reproductive activity, reduced genetic damage, and increased longevity among the oldest animals. These findings indicate a potential relationship between Epithalon treatment and
Note: Individual results may vary. This peptide is not FDA-approved for the treatment, cure, or prevention of any disease, and its use may be considered investigational and not for human or animal consumption. The information is based on published research and is educational in nature. It should not be interpreted as medical advice. Individuals should consult with a licensed healthcare provider to discuss any plans of care.
Anisimov, V. N., Khavinson, V. Kh., Popovich, I. G., Zabezhinski, M. A., Alimova, I. N., Rosenfeld, S. V., Zavarzina, N. Y., Semenchenko, A. V., & Yashin, A. I. (2003) ‘Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice’, Biogerontology, 4(4), 193–202. Available at: https://doi.org/10.1023/a:1025114230714 (Accessed: 9 November 2025).
Khavinson, V. Kh., Bondarev, I. E., & Butyugov, A. A. (2003) ‘Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells’, Bulletin of Experimental Biology and Medicine, 135(6), 590–592. Available at: https://doi.org/10.1023/a:1025493705728 (Accessed: 9 November 2025).
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