BPC-157 (Body Protection Compound-157) is a synthetic peptide made up of 15 amino acids and derived from a naturally occurring protective protein found in the stomach. It has been studied for its ability to promote healing and tissue regeneration in various organs and systems, particularly in the gastrointestinal tract, muscles, tendons, and nerves.
The peptide is believed to work by enhancing the formation of new blood vessels, increasing collagen production, and activating growth factors that drive tissue repair. It also appears to regulate inflammatory pathways and support the body’s nitric oxide system, which together contribute to improved recovery and reduced inflammation at the cellular level.
BPC-157 has shown the following potential in studies:
Additional research is needed to confirm potential benefits and research indications.
Tendon Healing Study (Staresinic et al., 2003)
In a rat model of Achilles tendon transection, BPC-157 treatment was associated with faster tendon recovery and increased fibroblast activity compared with controls. These findings suggest that BPC-157 may influence cellular processes involved in tendon repair, though causation cannot be established from this study alone.
Muscle Regeneration Study (Staresinic et al., 2006)
In rats with surgically injured quadriceps muscles, administration of BPC-157 correlated with improved structural and functional muscle recovery, along with reduced fibrosis. The results indicate a potential relationship between BPC-157 exposure and enhanced tissue healing responses.
Spinal Cord Injury Recovery Study (Perović et al., 2019)
Animal data demonstrated that rats receiving BPC-157 after spinal cord injury exhibited smaller lesion areas and better motor outcomes than controls. These findings imply possible neuroprotective associations, though further research is needed to confirm any direct regenerative effects.
Note: Individual results may vary. This peptide is not FDA-approved for the treatment, cure, or prevention of any disease, and its use may be considered investigational and not for human or animal consumption. The information is based on published research and is educational in nature. It should not be interpreted as medical advice. Individuals should consult with a licensed healthcare provider to discuss any plans of care.
Staresinic, M., Sebecic, B., Patrlj, L., Jadrijevic, S., Suknaic, S., Perovic, D., Aralica, G., Zarkovic, N., Borovic, S., Srdjak, M., Hajdarevic, K., Kopljar, M., Batelja, L., Boban-Blagaic, A., Turcic, I., Anic, T., Seiwerth, S., and Sikiric, P. (2003) ‘Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth’, Journal of Orthopaedic Research, 21, 976–983. Available at: https://onlinelibrary.wiley.com/doi/10.1016/S0736-0266%2803%2900110-4 (Accessed: 11 November 2025).
Staresinic, M., Petrovic, I., Novinscak, T., Jukic, I., Pevec, D., Suknaic, S., Kokic, N., Batelja, L., Brcic, L., Boban-Blagaic, A., Zoric, Z., Ivanovic, D., Ajduk, M., Sebecic, B., Patrlj, L., Sosa, T., Buljat, G., Anic, T., Seiwerth, S., and Sikiric, P. (2006) ‘Effective therapy of transected quadriceps muscle in rat: Gastric pentadecapeptide BPC 157’, Journal of Orthopaedic Research, 24, 1109–1117. Available at: https://onlinelibrary.wiley.com/doi/10.1002/jor.20089 (Accessed: 11 November 2025).
Perovic, D., Kolenc, D., Bilic, V., Somers, V., Bota, M., Pirkovic, N., Dobric, I., Barisic, I., Kunic, Z., Drmic, D., Stupnisek, M., Vukojevic, J., Vrdoljak, B., and Sikiric, P. (2019) ‘Stable gastric pentadecapeptide BPC 157 can improve the healing course of spinal cord injury and lead to functional recovery in rats’, Journal of Orthopaedic Surgery and Research, 14, 199. Available at: https://josr-online.biomedcentral.com/articles/10.1186/s13018-019-1242-6 (Accessed: 11 November 2025).
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